Salivary biological biomarkers for Alzheimer's disease

Dan Liang; Hao Lu

doi:10.1016/j.archoralbio.2019.06.004

Salivary biological biomarkers for Alzheimer's disease

Arch Oral Biol. 2019 Sep:105:5-12. doi: 10.1016/j.archoralbio.2019.06.004. Epub 2019 Jun 11.

Authors

Dan Liang¹, Hao Lu²

Affiliations

¹ Department of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, China.
² Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Research Institute of Stomatology and Shanghai Key Laboratory of Stomatology, Shanghai, China. Electronic address: dentallh@163.com.

PMID: 31203086
DOI: 10.1016/j.archoralbio.2019.06.004

Abstract

Alzheimer's disease (AD) is becoming a threat to aging population all over the world. The pathogenic process of AD is likely initiated many years before clinical onset, thus biomarkers for AD diagnosis are critical for the prevention and therapy for the disease at the early stage in order to reduce the global burden brought by the disease. Saliva is treated as a potential alternative and universal diagnostic fluid that can be collected noninvasively by participants with moderate training and without side effects. Several potential salivary biomarkers, which might prove to be significant diagnostic tools in AD, have been researched. We address here the present and the future of these salivary biological biomarkers for AD.

Keywords: Alzheimer’s disease; Biological biomarker; Saliva.

Publication types

Review

MeSH terms

Alzheimer Disease / diagnosis*
Biomarkers / chemistry*
Humans
Saliva / chemistry*

Substances

Biomarkers