Decreased static and increased dynamic global signal topography in major depressive disorder

Shaoqiang Han; Xiao Wang; Zongling He; Wei Sheng; Qijun Zou; Liang Li; Yang Yang; Xiaonan Guo; Yun-Shuang Fan; Jing Guo; FengMei Lu; Qian Cui; Huafu Chen

doi:10.1016/j.pnpbp.2019.109665

Decreased static and increased dynamic global signal topography in major depressive disorder

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30:94:109665. doi: 10.1016/j.pnpbp.2019.109665. Epub 2019 Jun 13.

Authors

Shaoqiang Han¹, Xiao Wang¹, Zongling He¹, Wei Sheng¹, Qijun Zou¹, Liang Li¹, Yang Yang¹, Xiaonan Guo¹, Yun-Shuang Fan¹, Jing Guo¹, FengMei Lu¹, Qian Cui², Huafu Chen³

Affiliations

¹ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; School of life Science and technology, Center for information in medicine, University of Electronic Science and Technology of China, Chengdu, China.
² School of Public Administration, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: qiancui26@gmail.com.
³ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; School of life Science and technology, Center for information in medicine, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: chenhf@uestc.edu.cn.

PMID: 31202912
DOI: 10.1016/j.pnpbp.2019.109665

Abstract

Major depressive disorder (MDD) has been linked to imbalanced communication among large-scale brain networks. However, the details of altered large-scale coordination of MDD remains unknown. To explore the altered large-scale functional organization in MDD. We used static and dynamic global signal (GS) topography, which are data-driven methods to explore altered relationship between global and local neuronal activities in MDD. Sixty three MDD patients and matched 63 healthy controls (HCs) were recruited in current study. Patients with MDD presented decreased static GS topography in bilateral parahippocampal gyrus and hippocampus gyrus. Meanwhile, patients with MDD presented increased variability of dynamic GS topography in the right ventromedial prefrontal cortex. This result may reflect the decreased and unstable whole brain functional coherence in MDD. The decreased static GS topography in the right parahippocampal gyrus was correlated with psychomotor retardation in patients with MDD. Our results presented that the altered static and dynamic GS topography can provide distinct evidence on the physiological mechanisms of MDD.

Keywords: Dynamic functional connectivity; Global signal topography; Major depressive disorder.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Case-Control Studies
Depressive Disorder, Major / physiopathology*
Female
Functional Neuroimaging
Hippocampus / physiopathology*
Humans
Magnetic Resonance Imaging
Male
Neural Pathways / physiopathology
Parahippocampal Gyrus / physiopathology*
Prefrontal Cortex / physiopathology*
Young Adult