ZnO-based nanostructured electrodes for electrochemical sensors and biosensors in biomedical applications

Nagaraj P Shetti; Shikandar D Bukkitgar; Kakarla Raghava Reddy; Ch Venkata Reddy; Tejraj M Aminabhavi

doi:10.1016/j.bios.2019.111417

ZnO-based nanostructured electrodes for electrochemical sensors and biosensors in biomedical applications

Biosens Bioelectron. 2019 Sep 15:141:111417. doi: 10.1016/j.bios.2019.111417. Epub 2019 Jun 8.

Authors

Nagaraj P Shetti¹, Shikandar D Bukkitgar², Kakarla Raghava Reddy³, Ch Venkata Reddy⁴, Tejraj M Aminabhavi⁵

Affiliations

¹ Electrochemistry and Materials Group, Department of Chemistry, K. L. E. Institute of Technology, Affiliated to Visvesvaraya Technological University, Gokul, Hubballi, 580030, Karnataka, India. Electronic address: npshetti@kleit.ac.in.
² Electrochemistry and Materials Group, Department of Chemistry, K. L. E. Institute of Technology, Affiliated to Visvesvaraya Technological University, Gokul, Hubballi, 580030, Karnataka, India.
³ School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia. Electronic address: reddy.chem@gmail.com.
⁴ School of Mechanical Engineering, Yeungnam University, Gyeongsan, 712-749, South Korea.
⁵ Department of Pharmaceuticals, Soniya College of Pharmacy, Dharwad, 580 002, Karnataka, India.

PMID: 31202187
DOI: 10.1016/j.bios.2019.111417

Abstract

Fascinating properties of ZnO nanostructures have created much interest due to their importance in health care and environmental monitoring. Current worldwide production and their wide range of applications signify ZnO to be a representative of multi-functional oxide material. Recent nanotechnological developments have stimulated the production of various forms of ZnO nanostructures such as nano-layers, nanoparticles, nanowires, etc. Due to their enhanced sensing properties, improved binding ability with biomolecules as well as biological activities have enabled them as suitable candidates for the fabrication of biosensor devices in the biomedical arena. In this review, the synthesis of ZnO nanostructures, mechanism of their interaction with biomolecules and their applications as sensors in health care area are discussed considering the biosensors for molecules with small molecular weight, infectious diseases, and pharmaceutical compounds.

Keywords: Biomedical applications; Biosensors; Electro-activity; Infectious diseases; Nanostructures; Zinc oxide.

Publication types

Review

MeSH terms

Animals
Biosensing Techniques / instrumentation*
Biosensing Techniques / methods
Electrochemical Techniques / instrumentation*
Electrochemical Techniques / methods
Electrodes
Equipment Design
Humans
Nanostructures / chemistry*
Nanostructures / ultrastructure
Nanotechnology / instrumentation
Nanotechnology / methods
Zinc Oxide / chemistry*

Substances

Zinc Oxide