Naloxegol for opioid-induced sphincter of Oddi spasm/dysfunction

BMJ Support Palliat Care. 2019 Dec;9(4):365-366. doi: 10.1136/bmjspcare-2019-001808. Epub 2019 Jun 14.

Abstract

The paper describes a case report of a patient with a significant history of opioid-induced dysfunction of the sphincter of Oddi, who required morphine sulfate to manage oral mucositis pain, and who was successfully treated with concomitant oral naloxegol (Moventig: Kyowa Kirin, Galashiels, UK).

Keywords: analgesics, opioid; naloxegol; narcotic antagonists; sphincter of Oddi.

MeSH terms

  • Administration, Oral
  • Analgesics, Opioid / adverse effects*
  • Carcinoma, Squamous Cell / complications
  • Humans
  • Male
  • Middle Aged
  • Morphinans / administration & dosage
  • Morphinans / therapeutic use*
  • Morphine / adverse effects*
  • Mucositis / complications
  • Mucositis / drug therapy
  • Narcotic Antagonists / administration & dosage
  • Narcotic Antagonists / therapeutic use*
  • Pain / complications
  • Pain / drug therapy
  • Polyethylene Glycols / administration & dosage
  • Polyethylene Glycols / therapeutic use*
  • Spasm / chemically induced*
  • Spasm / drug therapy*
  • Sphincter of Oddi Dysfunction / chemically induced
  • Sphincter of Oddi Dysfunction / drug therapy*
  • Sphincter of Oddi Dysfunction / physiopathology
  • Tonsillar Neoplasms / complications

Substances

  • Analgesics, Opioid
  • Morphinans
  • Narcotic Antagonists
  • Polyethylene Glycols
  • naloxegol
  • Morphine