ILCs in hematologic malignancies: Tumor cell killers and tissue healers

Semin Immunol. 2019 Feb:41:101279. doi: 10.1016/j.smim.2019.06.002. Epub 2019 Jun 12.

Abstract

Innate lymphoid cells (ILCs) have attracted considerable attention in the past years. As modulators of epithelial barrier immunology and homeostasis they play important roles in (auto)immunity and inflammation. Here we review the role of ILCs in hematologic malignancies, where ILCs act as efficient killer cells and as tissue healers, in the context of chemotherapy, radiotherapy and after allogeneic hematopoietic stem cell transplantation (HSCT).

Keywords: Allogeneic hematopoietic stem cell transplantation; Graft versus host disease; Innate lymphoid cells (ILCs); Mucositis; NK cells; Tumor immunology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Combined Modality Therapy / adverse effects
  • Combined Modality Therapy / methods
  • Cytotoxicity, Immunologic
  • Disease Susceptibility
  • Graft vs Host Disease / etiology
  • Hematologic Neoplasms / etiology*
  • Hematologic Neoplasms / metabolism*
  • Hematologic Neoplasms / pathology
  • Hematologic Neoplasms / therapy
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Hematopoietic Stem Cell Transplantation / methods
  • Humans
  • Immunity, Innate*
  • Immunotherapy, Adoptive
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / metabolism
  • Lymphocytes / immunology*
  • Lymphocytes / metabolism*
  • Transplantation, Homologous