Impact of genotypic susceptibility score on cART outcomes during primary HIV infection

J Med Virol. 2019 Oct;91(10):1891-1895. doi: 10.1002/jmv.25517. Epub 2019 Jun 27.

Abstract

To assess the impact of genotypic susceptibility score (GSS) on combined antiretroviral therapy (cART) outcomes during primary HIV infection (PHI) we retrospectively enrolled patients with PHI diagnosed between 2008 and 2015 at 9/24 Italian Network ACuTe HIV InfectiON centers. One hundred-seventy-six patients were enrolled. Of these, 55 (32.9%) patients started with more than three drugs and 11 (7.2%) started with a GSS < 3. Regimen's GSS (per 1 point increase) (adjusted odds ratio [aOR], 4.82; 95% confidence interval [CI], 1.62-14.28; P = .005) and baseline HIV-RNA (per 1 log10 increase) (aOR, 2.02; 95% CI, 1.09-3.73; P = .025) resulted associated with early cART initiation. In conclusion, regimen's GSS resulted to be associated to the time to cART initiation during PHI.

Keywords: GSS; HIV; primary HIV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • HIV / genetics*
  • HIV Infections / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies

Substances

  • Anti-HIV Agents