Epigenetic Factors of Disease

Ilham Alshiraihi; Mark A Brown

doi:10.3390/diseases7020042

Epigenetic Factors of Disease

Diseases. 2019 Jun 14;7(2):42. doi: 10.3390/diseases7020042.

Authors

Ilham Alshiraihi¹, Mark A Brown^{2

3

4

5}

Affiliations

¹ Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USA. Ilham.Alshiraihi@rams.colostate.edu.
² Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USA. Mark.Brown@colostate.edu.
³ Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA. Mark.Brown@colostate.edu.
⁴ Epidemiology Section, Colorado School of Public Health, Fort Collins, CO 80523, USA. Mark.Brown@colostate.edu.
⁵ Department of Ethnic Studies, Colorado State University, Fort Collins, CO 80523, USA. Mark.Brown@colostate.edu.

Abstract

The development of tissues involves the direction of specific programs for gene expression among distinct cell types. These programs are often established in a heritable state by virtue of epigenetic mechanisms and corresponding pathways of cellular memory. Thus, the broad synchronization in patterns of gene expression ultimately dictates cellular consequences. Aberrations in these epigenetic mechanisms are known to be associated with a range of diseases. Herein, we highlight epigenetic factors that, when aberrantly expressed, lead to a broad range of diseases. Further, we call upon the community of biomedical researchers to share their findings related to the epigenetic factors of disease.

Keywords: chromatin; epigenetics; nucleosome remodeling; post-translational modifications.

Publication types

Editorial