The aim of this study was to describe a core needle biopsy technique in the guinea pig (Cavia porcellus) and to assess the incidence of complications when applying this method. Biopsies were taken from the right hepatic lobe of 36 healthy guinea pigs under ultrasound guidance using a Tru-Cut needle. There were no immediate complications in 35 animals but ultrasound images showed a haemorrhage from the biopsy site in one guinea pig. The haemorrhage stopped after administering a sterile cooling dressing. One guinea pig died 13 days after the biopsy due to late complications. The procedure is in some animals associated with severe, potential life-threatening, complications. Assessment of the biopsy site by ultrasonography for 30 min after the procedure is recommended to allow timely handling of haemorrhage. The procedure is not recommended in animals with a suspected coagulopathy. Due to the risk of severe complications, this procedure should be restricted to guinea pigs where the result of the biopsy examination is expected to be valuable for the choice of treatment or prognosis. Owners should be made aware of the risks associated with the procedure.
Keywords: Core needle biopsy; Guinea pig; Liver.