Gene editing based hearing impairment research and therapeutics

Wen Kang; Zhuoer Sun; Xingle Zhao; Xueling Wang; Yong Tao; Hao Wu

doi:10.1016/j.neulet.2019.134326

Gene editing based hearing impairment research and therapeutics

Neurosci Lett. 2019 Sep 14:709:134326. doi: 10.1016/j.neulet.2019.134326. Epub 2019 Jun 10.

Authors

Wen Kang¹, Zhuoer Sun¹, Xingle Zhao¹, Xueling Wang², Yong Tao³, Hao Wu⁴

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, China; Ear Institute, Shanghai Jiaotong University School of Medicine, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, China.
² Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, China; Ear Institute, Shanghai Jiaotong University School of Medicine, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, China. Electronic address: xuelingwang2013@163.com.
³ Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, China; Ear Institute, Shanghai Jiaotong University School of Medicine, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, China. Electronic address: taoyent@foxmail.com.
⁴ Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, China; Ear Institute, Shanghai Jiaotong University School of Medicine, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, China. Electronic address: wuhao622@sina.com.

PMID: 31195050
DOI: 10.1016/j.neulet.2019.134326

Abstract

Hearing impairment affects 1 in 500 newborns worldwide and nearly one out of three people over the age of 65 (WHO, 2019). Hereditary hearing loss is the most common type of congenital deafness; genetic factors also affect deafness susceptibility. Gene therapies may preserve or restore natural sound perception, and have rescued deafness in multiple hereditary murine models. CRISPR-Cas9 and base editors (BEs) are newly developed gene editing technologies that can facilitate gene studies in the inner ear and provide therapeutic approaches for hearing impairment. Here, we present recent applications of gene editing in the inner ear.

Keywords: Base editing; CRISPR; Gene editing; Gene therapy; Hearing impairment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
CRISPR-Cas Systems / genetics*
Deafness / genetics*
Deafness / therapy*
Gene Editing / methods*
Gene Editing / trends
Genetic Therapy / methods*
Genetic Therapy / trends
Hearing Loss / genetics
Hearing Loss / therapy
Humans