Rapid detection of bacille Calmette-Guérin-associated mycotic aortic aneurysm using novel cell-free DNA assay

Vignesh Vudatha; Mark Ranson; Lily Blair; Asim A Ahmed

doi:10.1016/j.jvscit.2018.11.006

Rapid detection of bacille Calmette-Guérin-associated mycotic aortic aneurysm using novel cell-free DNA assay

J Vasc Surg Cases Innov Tech. 2019 Apr 28;5(2):143-148. doi: 10.1016/j.jvscit.2018.11.006. eCollection 2019 Jun.

Authors

Vignesh Vudatha¹, Mark Ranson², Lily Blair³, Asim A Ahmed³

Affiliations

¹ Department of Surgery, University of Central Florida College of Medicine, Orlando, Fla.
² Department of General Surgery, Division of Vascular Surgery, Florida Hospital Orlando, Orlando, Fla.
³ Karius, Inc, Redwood City, Calif.

Abstract

Intravesical instillation of bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, is an adjuvant immunotherapy for bladder carcinoma. Typical complications include fever, malaise, and dysuria. However, more severe complications have been reported, including granulomatous pneumonitis, BCG sepsis, and vascular infections. We present a case of an infrarenal abdominal aortic aneurysm complicated by iliopsoas abscess 2 years after BCG treatment and discuss a novel diagnostic tool for mycobacterial strain identification.

Keywords: BCG; Cell-free DNA; Mycobacterium; Mycotic aortic aneurysm; Next-generation sequencing.

Publication types

Case Reports