Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure

ASAIO J. 2020 Apr;66(4):423-432. doi: 10.1097/MAT.0000000000001018.

Abstract

Children with end-stage lung failure awaiting lung transplant would benefit from improvements in artificial lung technology allowing for wearable pulmonary support as a bridge-to-transplant therapy. In this work, we designed, fabricated, and tested the Pediatric MLung-a dual-inlet hollow fiber artificial lung based on concentric gating, which has a rated flow of 1 L/min, and a pressure drop of 25 mm Hg at rated flow. This device and future iterations of the current design are designed to relieve pulmonary arterial hypertension, provide pulmonary support, reduce ventilator-associated injury, and allow for more effective therapy of patients with end-stage lung disease, including bridge-to-transplant treatment.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Artificial Organs*
  • Child
  • Equipment Design
  • Humans
  • Lung Transplantation
  • Respiratory Insufficiency / therapy*