Aims: Hypothyroidism is the most commonly encountered hormone deficiency determined in all age groups. Serum galectin-3 concentrations that play important roles in cellular proliferation and adhesion were not studied before in hypothyroidism. In this study, we aimed to determine the relationship between serum galectin-3 concentrations and hypothyroidism. Methods: A total of 83 individuals, 46 patients with hypothyroidism and 37 healthy controls, were included in the study. Among 46 patients with hypothyroidism, anti-TPO concentrations were higher than the reference range in 22 of them while it was in reference range in remaining 24 patients. Routine laboratory data (glucose, urea, creatinine, AST, ALT, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, TSH, fT4, fT3, anti-TPO, anti-Tg) and galectin-3 concentrations were compared between the groups. Galectin-3 concentrations were measured by Enzyme linked immunosorbent assay. Results: Galectin-3 concentrations were significantly higher in patients with hypothyroidism compared to the control group (2.89 (1.17-10.79); 1.95 (1.15-6.11) ng/mL, p = .001, respectively). There was a positive correlation between galectin-3 concentrations and TSH, anti-Tg and triglyceride concentrations; while a negative correlation was present between fT4 and fT3 and galectin-3 concentrations (p < .05). Conclusions: For the first time in the literature, we determined elevated serum galectin-3 concentrations in patients with hypothyroidism compared with healthy controls. We believe that increased galectin-3 concentrations may play a role in hyperplasia of thyroid gland that is important in pathogenesis of hypothyroidism and high concentrations of galectin-3 may be associated with hypertriglyceridemia seen in hypothyroidism.
Keywords: Galectin-3; hyperplasia; hypertriglyceridemia; hypothyroidism; thyroid gland.