This study evaluated the success and failure rates as well as the final results following 2-stage revision total knee arthroplasty (TKA) for periprosthetic joint infection (PJI). Particular emphasis was placed on comparing patients with rheumatoid arthritis (RA) and non-RA patients. A total of 140 knees that required 2-stage revision for PJI after TKA were analyzed. Mean patient age at first revision TKA was 67.9 years (range, 43 to 89 years), and mean time from second-stage revision to final follow-up was 53.3 months (range, 26 to 127 months). Thirty-eight of the 140 knees (27.1%) demonstrated recurrence of infection after first 2-stage revision. Of these, 8 required another 2-stage revision, 25 required knee arthrodesis, and 2 required amputation; 3 patients refused further treatment or were lost to follow-up. There was no recurrence of infection. No statistically significant differences were observed between the RA and non-RA groups in terms of success or failure rate (P=.6) according to Diaz-Ledezma and Knee Society Scores (P=.3). These findings indicate reinfection rates and final results were similar in RA and non-RA patients following revision TKA for PJI. [Orthopedics. 2019; 42(5):e472-e476.].
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