Dexamethasone intravitreal implant (OZURDEX®) for macular edema secondary to noninfectious uveitis: a review of the literature

Ther Deliv. 2019 Jun 1;10(6):343-351. doi: 10.4155/tde-2019-0024. Epub 2019 Jun 11.

Abstract

Macular edema (ME) is the leading cause of visual loss in uveitis and may persist long after ocular inflammation has been resolved. Local steroids are the first line treatment for uveitis and uveitic ME. Dexamethasone intravitreal implant (OZURDEX®; Allergan, Inc., CA, USA) has been used to treat diabetic ME and ME secondary to retinal vein occlusion. Recent studies have also demonstrated that Ozurdex may be effective treatment for patients with persistent uveitic ME. In this review, we present the results of the real word studies concerning the efficacy and safety of Ozurdex for the treatment of uveitic ME.

Keywords: dexamethasone intravitreal implant; macular edema; ocular inflammation; ozurdex; steroid; uveitis.

Publication types

  • Review

MeSH terms

  • Cataract / chemically induced
  • Cataract / epidemiology
  • Clinical Trials as Topic
  • Dexamethasone / administration & dosage*
  • Dexamethasone / adverse effects
  • Disease Progression
  • Drug Implants / administration & dosage*
  • Drug Implants / adverse effects
  • Glucocorticoids / administration & dosage*
  • Glucocorticoids / adverse effects
  • Humans
  • Intraocular Pressure / drug effects
  • Intravitreal Injections / adverse effects
  • Macular Edema / drug therapy*
  • Macular Edema / immunology
  • Treatment Outcome
  • Uveitis / complications
  • Uveitis / diagnosis
  • Uveitis / drug therapy*
  • Uveitis / immunology

Substances

  • Drug Implants
  • Glucocorticoids
  • Dexamethasone