Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging

Hui Li; Chang-Hee Lee; Injae Shin

doi:10.1021/acs.orglett.9b01530

Preparation of a Multiple-Targeting NIR-Based Fluorogenic Probe and Its Application for Selective Cancer Cell Imaging

Org Lett. 2019 Jun 21;21(12):4628-4631. doi: 10.1021/acs.orglett.9b01530. Epub 2019 Jun 3.

Authors

Hui Li¹, Chang-Hee Lee¹, Injae Shin¹

Affiliation

¹ Department of Chemistry , Yonsei University , Seoul 03722 , Republic of Korea.

PMID: 31184188
DOI: 10.1021/acs.orglett.9b01530

Abstract

To improve cancer selectivity of imaging agents, we synthesized the triple-targeting, near-infrared (NIR) based fluorogenic probe, Oct-FK(PBA)-NIR. The new probe consists of (1) octreotide as a synthetic ligand of somatostatin receptors, (2) a H₂O₂-responsive phenylboronic acid, (3) a dipeptide substrate for cathepsin B, and (4) a NIR fluorophore. The results of cell studies show that the probe can be used for selective imaging of cancer cells in the NIR range without interference with normal cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CHO Cells
Cricetulus
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry*
HeLa Cells
Humans
Molecular Structure
Octreotide / chemical synthesis
Octreotide / chemistry*
Optical Imaging*

Substances

Fluorescent Dyes
Octreotide