[Molecular basis of intratumoral heterogeneity of urinary tract urothelial carcinoma]

Y I Osmanov; J A Gaibov; E A Kogan; L M Rapoport

[Molecular basis of intratumoral heterogeneity of urinary tract urothelial carcinoma]

Urologiia. 2019 Apr:(1):126-130.

[Article in Russian]

Authors

Y I Osmanov^{1

2

3}, J A Gaibov^{1

2

3}, E A Kogan^{1

2

3}, L M Rapoport^{1

2

3}

Affiliations

¹ ) Department of Pathology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
² ) Department of Pathology, Scientific Clinical Center of Russian Railways, Moscow, Russia.
³ ) Department of Urology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

PMID: 31184030

Abstract

In the article the main mechanisms of molecular pathogenesis of urinary tract urothelial carcinoma are presented. Two different molecular pathways that determine the development of non-invasive and invasive urothelial carcinoma, the immunohistochemical spectrum of stem markers and aspects of the carcinogenesis of multifocal and recurrent tumors are considered.

Keywords: intratumoral heterogeneity; molecular classification; stem cell; urothelial carcinoma.

MeSH terms

Biomarkers
Carcinoma, Transitional Cell* / genetics
Humans
Neoplasm Recurrence, Local
Urinary Bladder Neoplasms* / genetics
Urinary Tract*
Urologic Neoplasms*

Substances

Biomarkers