A trace alkaloid, oleraisoindole A from Portulaca oleracea L. and its anticholinesterase effect

Yifei Ma; Xuetao Li; Wenjie Zhang; Xixiang Ying; Didier Stien

doi:10.1080/14786419.2019.1627356

A trace alkaloid, oleraisoindole A from Portulaca oleracea L. and its anticholinesterase effect

Nat Prod Res. 2021 Jan;35(2):350-353. doi: 10.1080/14786419.2019.1627356. Epub 2019 Jun 10.

Authors

Yifei Ma¹, Xuetao Li¹, Wenjie Zhang¹, Xixiang Ying¹, Didier Stien²

Affiliations

¹ School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, P.R. China.
² Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Sorbonne Universités, UPMC Univ Paris 06, CNRS, Paris, France.

PMID: 31180242
DOI: 10.1080/14786419.2019.1627356

Abstract

A new trace alkaloid possessing the lignan structure, named oleraisoindole A, was obtained from the extract of the Portulaca oleracea L.. The structure of oleraisoindole A was elucidated by 1D and 2D NMR and high resolution electrospray ionization time-of-flight mass spectroscopic methods. The compound presented an anticholinesterase effect with the IC₅₀ value of 60.4 μM.

Keywords: Portulaca oleracea L.; alkaloids; anticholinesterase effect.

MeSH terms

Cholinesterase Inhibitors / administration & dosage
Cholinesterase Inhibitors / chemistry*
Cholinesterase Inhibitors / pharmacology*
Dose-Response Relationship, Drug
Isoindoles / administration & dosage
Isoindoles / chemistry*
Isoindoles / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Structure
Portulaca / chemistry*
Spectrometry, Mass, Electrospray Ionization / methods

Substances

Cholinesterase Inhibitors
Isoindoles
oleraisoindole