Recent advances in biorefinery of astaxanthin from Haematococcus pluvialis

Kuan Shiong Khoo; Sze Ying Lee; Chien Wei Ooi; Xiaoting Fu; Xiaoling Miao; Tau Chuan Ling; Pau Loke Show

doi:10.1016/j.biortech.2019.121606

Recent advances in biorefinery of astaxanthin from Haematococcus pluvialis

Bioresour Technol. 2019 Sep:288:121606. doi: 10.1016/j.biortech.2019.121606. Epub 2019 Jun 4.

Authors

Kuan Shiong Khoo¹, Sze Ying Lee², Chien Wei Ooi³, Xiaoting Fu⁴, Xiaoling Miao⁵, Tau Chuan Ling⁶, Pau Loke Show⁷

Affiliations

¹ Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia Campus, Jalan Broga, Semenyih 43500, Selangor Darul Ehsan, Malaysia.
² Department of Chemical Engineering, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Sungai Long Campus, Kajang 43000, Selangor, Malaysia.
³ Chemical Engineering Discipline, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia.
⁴ College of Food Science & Engineering, Ocean University of China, Qingdao 266000, China.
⁵ State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai 200240, China; Biomass Energy Research Center, Shanghai Jiao Tong University, Shanghai 200240, China.
⁶ Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
⁷ Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia Campus, Jalan Broga, Semenyih 43500, Selangor Darul Ehsan, Malaysia. Electronic address: PauLoke.Show@nottingham.edu.my.

PMID: 31178260
DOI: 10.1016/j.biortech.2019.121606

Abstract

Haematococcus pluvialis is one of the most abundant sources of natural astaxanthin as compared to others microorganism. Therefore, it is important to understand the biorefinery of astaxanthin from H. pluvialis, starting from the cultivation stage to the downstream processing of astaxanthin. The present review begins with an introduction of cellular morphologies and life cycle of H. pluvialis from green vegetative motile stage to red non-motile haematocyst stage. Subsequently, the conventional biorefinery methods (e.g., mechanical disruption, solvent extraction, direct extraction using vegetable oils, and enhanced solvent extraction) and recent advanced biorefinery techniques (e.g., supercritical CO₂ extraction, magnetic-assisted extraction, ionic liquids extraction, and supramolecular solvent extraction) were presented and evaluated. Moreover, future prospect and challenges were highlighted to provide a useful guide for future development of biorefinery of astaxanthin from H. pluvialis. The review aims to serve as a present knowledge for researchers dealing with the bioproduction of astaxanthin from H. pluvialis.

Keywords: Astaxanthin; Biorefinery; Cultivation; Haematococcus pluvialis; Pretreatment.

Publication types

Review

MeSH terms

Chlorophyceae
Ionic Liquids*
Plant Oils
Xanthophylls*

Substances

Ionic Liquids
Plant Oils
Xanthophylls
astaxanthine