Diagnosis and Prognosis of Canine Cutaneous Mast Cell Tumors

Matti Kiupel; Melinda Camus

doi:10.1016/j.cvsm.2019.04.002

Diagnosis and Prognosis of Canine Cutaneous Mast Cell Tumors

Vet Clin North Am Small Anim Pract. 2019 Sep;49(5):819-836. doi: 10.1016/j.cvsm.2019.04.002. Epub 2019 Jun 6.

Authors

Matti Kiupel¹, Melinda Camus²

Affiliations

¹ Michigan State University Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road, Room 152A, Lansing, MI 48910, USA; Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road, Room 152A, Lansing, MI 48910, USA. Electronic address: kiupel@dcpah.msu.edu.
² Department of Pathology, College of Veterinary Medicine, University of Georgia, 501 D.W. Brooks Drive, Athens, GA 30602, USA.

PMID: 31178200
DOI: 10.1016/j.cvsm.2019.04.002

Abstract

Canine cutaneous mast cell tumors (MCTs) are among the most common canine cutaneous tumors, with highly variable biological behavior. This review describes in detail current approaches for cytologic and histologic diagnosis and prognosis, including advantages and limitations of cytologic and histologic grading and utilization of molecular markers, for example, Ki67, AgNORs, KIT expression, and c-Kit mutations, for a more accurate detection of aggressive MCTs. Furthermore, the current approach to evaluate surgical margins and spread to local lymph nodes is discussed.

Keywords: Canine; Grading; Mast cell tumor; c-Kit.

Publication types

Review

MeSH terms

Animals
Biomarkers, Tumor
Biopsy / methods
Biopsy / veterinary
Dog Diseases / diagnosis*
Dog Diseases / pathology
Dogs
Mastocytosis, Cutaneous / diagnosis
Mastocytosis, Cutaneous / pathology
Mastocytosis, Cutaneous / veterinary*
Neoplasm Metastasis / pathology
Neoplasm Recurrence, Local
Neoplasm Staging / veterinary
Prognosis

Substances

Biomarkers, Tumor