PHASER: A platform for clinical translation of FLASH cancer radiotherapy

Peter G Maxim; Sami G Tantawi; Billy W Loo Jr

doi:10.1016/j.radonc.2019.05.005

PHASER: A platform for clinical translation of FLASH cancer radiotherapy

Radiother Oncol. 2019 Oct:139:28-33. doi: 10.1016/j.radonc.2019.05.005. Epub 2019 Jun 6.

Authors

Peter G Maxim¹, Sami G Tantawi², Billy W Loo Jr³

Affiliations

¹ Department of Radiation Oncology, Indiana University School of Medicine, United States. Electronic address: PMaxim@iu.edu.
² SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025, United States. Electronic address: Tantawi@slac.stanford.edu.
³ Department of Radiation Oncology, Stanford University School of Medicine, United States; Stanford Cancer Institute, Stanford University School of Medicine, United States. Electronic address: BWLoo@Stanford.edu.

PMID: 31178058
DOI: 10.1016/j.radonc.2019.05.005

Abstract

Pluridirectional high-energy agile scanning electronic radiotherapy (PHASER) is next-generation medical linac technology for ultra-rapid highly conformal image-guided radiation, fast enough to "freeze" physiological motion, affording improved accuracy, precision, and potentially superior FLASH radiobiological therapeutic index. Designed for compactness, economy, and clinical efficiency, it is also intended to address barriers to global access to curative radiotherapy.

Keywords: FLASH; PHASER; Ultra-rapid radiation therapy; Very high-energy electron radiotherapy.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Humans
Neoplasms / radiotherapy*
Particle Accelerators
Radiotherapy Dosage
Radiotherapy, Conformal / methods*
Radiotherapy, High-Energy / methods*
Radiotherapy, Image-Guided / methods*