Periodontal disease (PD) is an infection-driven chronic inflammatory disease characterized by the inflammation of tooth-supporting tissues and the destruction of the associated alveolar bone. The immune response of the host to periodontal pathogens infection determines the course and progress of the disease. The effects of secreting cytokines interferon-gamma (IFN-γ) and interleukin-17 (IL-17) of T helper 1 cells (Th1) and T helper 17 cells (Th17) on the development of periodontitis has attracted much attention. IFN-γ is a potential immune-modulatory cytokine and can mediate cellular immune responses by activating various immune cells of the host such as macrophages. As one of the most potential bone physiological regulation mediators, IL-17 is closely related with alveolar bone resorption in periodontitis. This review elaborated the relationship between IFN-γ and IL-17 in the progress of periodontitis, providing new explanations into the development of periodontitis and alveolar bone destruction caused by the host immune response.
牙周炎是以牙龈炎症和牙槽骨进行性破坏为特征的慢性感染性疾病，宿主感染微生物后的免疫炎症反应决定疾病的过程和进展。辅助性T细胞（T helper，Th）1和Th17特征性分泌因子干扰素γ和白细胞介素17（interleukin-17，IL-17）在牙周炎发生发展的作用一直备受关注。干扰素γ是具有潜在免疫调节作用的细胞因子，可以激活机体多种免疫细胞（如巨噬细胞），介导细胞免疫应答。IL-17作为炎症因子中最具潜力的骨生理稳定调节介质，可直接影响牙槽骨吸收及牙周炎的发生发展。本文就Th 1和Th17特征性分泌因子干扰素γ及IL-17在牙周炎发生发展中的作用进行综述。.
Keywords: Alveolar bone loss; Interferon-gamma; Interleukin-17; Periodontitis.