Circadian activity rhythm and fragmentation are associated with sleep-wake patterns and sleep quality in patients with stroke

NeuroRehabilitation. 2019;44(3):353-360. doi: 10.3233/NRE-182665.

Abstract

Background: Activity levels and disturbances of the sleep-wake pattern affect health and quality of life and need to be further explored in patients with stroke.

Objective: To evaluate activity levels and their association with sleep-wake patterns in patients with stroke.

Methods: Ten adults with (51±6 years) and 10 without stroke (52±7 years) participated in the study; they were matched on age, sex and educational level. Neurological status, motor function, sleep quality, and activity levels were measured. The groups were compared using Student t-tests and the association between the measures was assessed using Pearson's correlation.

Results: Compared to people without stroke, those with stroke had worse sleep quality (p = 0.044), twice lower 24h-activity levels (p < 0.0001), higher interdaily stability and intradaily variability, lower activity during the most active 10 h and during the least active 5 h. Sleep quality was associated with activity level (r= -0.72) and with within-day activity variability (r= 0.53).

Conclusions: Activity level and fragmentation are associated with sleep-wake patterns and sleep quality in patients with stroke.

Keywords: Stroke; activity levels; neurorehabilitation; sleep-wake cycle.

MeSH terms

  • Adult
  • Aged
  • Circadian Rhythm / physiology*
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Quality of Life / psychology*
  • Sleep / physiology*
  • Sleep Stages / physiology
  • Stroke / physiopathology*
  • Stroke / psychology*
  • Wakefulness / physiology*