Sphingolipids and the unfolded protein response

Melissa K Bennett; Craig T Wallington-Beddoe; Stuart M Pitson

doi:10.1016/j.bbalip.2019.06.002

Sphingolipids and the unfolded protein response

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1483-1494. doi: 10.1016/j.bbalip.2019.06.002. Epub 2019 Jun 5.

Authors

Melissa K Bennett¹, Craig T Wallington-Beddoe², Stuart M Pitson³

Affiliations

¹ Centre for Cancer Biology, University of South Australia and SA Pathology, UniSA CRI Building, North Tce, Adelaide, SA 5001, Australia.
² Centre for Cancer Biology, University of South Australia and SA Pathology, UniSA CRI Building, North Tce, Adelaide, SA 5001, Australia; Adelaide Medical School, University of Adelaide, Adelaide, SA 5001, Australia; Flinders Medical Centre, Bedford Park, SA 5042, Australia; College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.
³ Centre for Cancer Biology, University of South Australia and SA Pathology, UniSA CRI Building, North Tce, Adelaide, SA 5001, Australia; Adelaide Medical School, University of Adelaide, Adelaide, SA 5001, Australia; School of Biological Sciences, University of Adelaide, Adelaide, SA 5000, Australia. Electronic address: stuart.pitson@unisa.edu.au.

PMID: 31176037
DOI: 10.1016/j.bbalip.2019.06.002

Abstract

The unfolded protein response (UPR) is a response by the endoplasmic reticulum to stress, classically caused by any disruption to cell homeostasis that results in an accumulation in unfolded proteins. However, there is an increasing body of research demonstrating that the UPR can also be activated by changes in lipid homeostasis, including changes in sphingolipid metabolism. Sphingolipids are a family of bioactive lipids with important roles in both the formation and integrity of cellular membranes, and regulation of key cellular processes, including cell proliferation and apoptosis. Bi-directional interactions between sphingolipids and the UPR have now been observed in a range of diseases, including cancer, diabetes and liver disease. Determining how these two key cellular components influence each other could play an important role in deciphering the causes of these diseases and potentially reveal new therapeutic approaches.

Keywords: Ceramide; Endoplasmic reticulum stress; Sphingolipids; Unfolded protein response.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Apoptosis
Cell Proliferation
Diabetes Mellitus / metabolism
Humans
Liver Diseases / metabolism
Neoplasms / metabolism
Sphingolipids / metabolism*
Unfolded Protein Response*

Substances

Sphingolipids