DUX4 Pathological Expression: Causes and Consequences in Cancer

Carla Dib; Vlada Zakharova; Ekaterina Popova; Ekaterina Kiseleva; Boris Chernyak; Marc Lipinski; Yegor S Vassetzky

doi:10.1016/j.trecan.2019.03.001

DUX4 Pathological Expression: Causes and Consequences in Cancer

Trends Cancer. 2019 May;5(5):268-271. doi: 10.1016/j.trecan.2019.03.001. Epub 2019 Apr 16.

Authors

Carla Dib¹, Vlada Zakharova², Ekaterina Popova³, Ekaterina Kiseleva⁴, Boris Chernyak³, Marc Lipinski¹, Yegor S Vassetzky⁵

Affiliations

¹ UMR 8126, CNRS, Univ. Paris-Sud, Université Paris Saclay, Institut Gustave Roussy, F-94805 Villejuif, France; LIA 1066 LFR2O French-Russian Joint Cancer Research Laboratory, 94805 Villejuif, France.
² UMR 8126, CNRS, Univ. Paris-Sud, Université Paris Saclay, Institut Gustave Roussy, F-94805 Villejuif, France; LIA 1066 LFR2O French-Russian Joint Cancer Research Laboratory, 94805 Villejuif, France; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia; CNRS UMR7216 "Epigénétique et Destin Cellulaire" Université Paris Diderot, Paris 7, France.
³ Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
⁴ Koltzov Institute of Developmental Biology, Moscow 117334, Russia.
⁵ UMR 8126, CNRS, Univ. Paris-Sud, Université Paris Saclay, Institut Gustave Roussy, F-94805 Villejuif, France; LIA 1066 LFR2O French-Russian Joint Cancer Research Laboratory, 94805 Villejuif, France; Koltzov Institute of Developmental Biology, Moscow 117334, Russia. Electronic address: yegor.vassetzky@cnrs.fr.

PMID: 31174839
DOI: 10.1016/j.trecan.2019.03.001

Abstract

DUX4, a double homeobox transcription factor, has been mostly studied in facioscapulohumeral dystrophy (FSHD), a pathology linked to a deletion of subtelomeric repeats on chromosome 4q. More recently, however, the gene has been associated with various sarcomas and haematological malignancies. Drugs developed for FSHD could be tested on cancer cells to develop efficient treatment strategies for both pathologies.

Keywords: DUX4; FSHD; leukaemia; sarcoma.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Disease Susceptibility
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic*
Gene Rearrangement
Homeodomain Proteins / chemistry
Homeodomain Proteins / genetics*
Homeodomain Proteins / metabolism
Humans
Molecular Targeted Therapy
Neoplasms / genetics*
Neoplasms / metabolism
Neoplasms / pathology
Neoplasms / therapy
Protein Binding
Protein Interaction Domains and Motifs

Substances

DUX4L1 protein, human
Homeodomain Proteins