Abstract
The tolerance of ribosomal peptide translation for helical aromatic oligoamide foldamers appended as initiators has been investigated. Small cationic foldamer side-chains were shown to expand the range of foldamer-peptide hybrids that can be produced by the ribosome to more rigid sequences.
MeSH terms
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Amides / chemistry*
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Amino Acids / chemistry
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Models, Molecular
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Molecular Conformation
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Peptide Elongation Factors / chemistry
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Peptides / chemistry*
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Protein Biosynthesis
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Protein Folding
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Ribosomes / chemistry
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Ribosomes / metabolism*
Substances
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Amides
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Amino Acids
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Peptide Elongation Factors
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Peptides
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factor EF-P