Optimizing aromatic oligoamide foldamer side-chains for ribosomal translation initiation

Chem Commun (Camb). 2019 Jun 20;55(51):7366-7369. doi: 10.1039/c9cc03547h.

Abstract

The tolerance of ribosomal peptide translation for helical aromatic oligoamide foldamers appended as initiators has been investigated. Small cationic foldamer side-chains were shown to expand the range of foldamer-peptide hybrids that can be produced by the ribosome to more rigid sequences.

MeSH terms

  • Amides / chemistry*
  • Amino Acids / chemistry
  • Models, Molecular
  • Molecular Conformation
  • Peptide Elongation Factors / chemistry
  • Peptides / chemistry*
  • Protein Biosynthesis
  • Protein Folding
  • Ribosomes / chemistry
  • Ribosomes / metabolism*

Substances

  • Amides
  • Amino Acids
  • Peptide Elongation Factors
  • Peptides
  • factor EF-P