Six new monacolin analogs from red yeast rice

Chin J Nat Med. 2019 May 20;17(5):394-400. doi: 10.1016/S1875-5364(19)30046-9.

Abstract

Six novel monacolin analogs, monacolins V1-V6 (1-6), together with seven known ones (7-13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR (1H-1HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Monacolins V2 (2) and V3 (3) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.

Keywords: Monascus purpureus; Red yeast rice, Monacolins.

MeSH terms

  • Acetates / chemistry
  • Animals
  • Biological Products / chemistry*
  • Cell Line, Transformed
  • Hydroxybutyrates / chemistry*
  • Hydroxybutyrates / isolation & purification
  • Hydroxybutyrates / pharmacology
  • Lipid Peroxidation / drug effects
  • Lipopolysaccharides / pharmacology
  • Molecular Structure
  • Naphthalenes / chemistry*
  • Naphthalenes / isolation & purification
  • Naphthalenes / pharmacology

Substances

  • Acetates
  • Biological Products
  • Hydroxybutyrates
  • Lipopolysaccharides
  • Naphthalenes
  • red yeast rice
  • ethyl acetate