Do Calcium and Potassium Levels Influence Ductal Patency in Preterm Infants?

Abstract

Objective: We investigated the relationship of serum potassium (K⁺) and ionized calcium (iCa²⁺) levels with the persistence of ductus arteriosus.

Study design: This retrospective cohort study included infants with birth weight < 1,500 g and gestational age < 32 weeks. Serum K⁺ and iCa²⁺ levels at the 1st and 48th hour of life were measured from samples. The difference between the two levels was calculated for both serum K⁺ (ΔK⁺) and iCa²⁺ (ΔCa²⁺). These values were compared between hemodynamically significant patent ductus arteriosus (hsPDA) and non-hsPDA.

Results: Of 1,322 hospitalized preterm nonates, 1,196 were included in the study. Mean serum K⁺ levels at the 1st and 48th hour were higher and iCa²⁺ levels at the 1st and 48th hour were lower in hsPDA and non-hsPDA, respectively (p < 0.001). Ionized ΔCa²⁺ (-0.06 ± 0.13 vs. -0.02 ± 0.12 mmol/L) was higher in hsPDA (p < 0.001).

Conclusion: We demonstrated that serum K⁺ and iCa²⁺ level might play a role in ductal constriction.