Purpose: Propafenone hydrochloride has been widely used for the treatment of supraventricular and ventricular arrhythmias. We present a case report of an 81-year-old patient with propafenone-associated gross hematuria.
Methods: The Naranjo Adverse Drug Reaction Probability Scale was used to assess causality. We also performed a literature search to find publications that report propafenone-associated gross hematuria.
Findings: The Naranjo scale generated a score of 6, suggesting a probable association between gross hematuria and propafenone therapy. Thirteen publications that reported an association between gross hematuria and propafenone administration were found.
Implications: A probable association exists between gross hematuria and propafenone.
Keywords: antiarrhythmic medication; gross hematuria; paroxysmal atrial fibrillation; propafenone.
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