Gene Regulation: Analog to Digital Conversion of Transcription Factor Gradients

Dimitrios K Papadopoulos; Pavel Tomancak

doi:10.1016/j.cub.2019.04.052

Gene Regulation: Analog to Digital Conversion of Transcription Factor Gradients

Curr Biol. 2019 Jun 3;29(11):R422-R424. doi: 10.1016/j.cub.2019.04.052.

Authors

Dimitrios K Papadopoulos¹, Pavel Tomancak²

Affiliations

¹ MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Electronic address: Dimitrios.papadopoulos@igmm.ed.ac.uk.
² Max-Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. Electronic address: tomancak@mpi-cbg.de.

PMID: 31163148
DOI: 10.1016/j.cub.2019.04.052

Abstract

Transcription factor gradients trigger differential transcriptional responses based on concentration. But how, in some cases, do target genes maintain uniform transcription across portions of the gradient? Lessons from Drosophila demonstrate that organization of transcription into 'hubs' can lead to local increases in transcription factor concentration.

Publication types

Comment

MeSH terms

Animals
Drosophila / genetics*
Drosophila Proteins*
Gene Expression Regulation, Developmental
Nuclear Proteins
Transcription Factors

Substances

Drosophila Proteins
Nuclear Proteins
Transcription Factors
zld protein, Drosophila