Efficacy of posttreatment radioiodine scanning in patients with differentiated thyroid cancer

Head Neck. 2019 Sep;41(9):3235-3240. doi: 10.1002/hed.25833. Epub 2019 Jun 4.

Abstract

Background: Differentiated thyroid cancers often require radioiodine treatment followed by posttreatment scan. We aimed in this study to assess the utility of the posttreatment radioiodine scan in this population.

Methods: An analysis of patients who received radioiodine treatment at Rambam Campus, during 2006-2013. Scans showing remnant normal thyroid tissue were considered as normal. Positive uptake was defined as uptake in the lateral neck or distant sites.

Results: A total of 455 patients were analyzed, 68% had T1-T2 and 28% had positive lymph nodes. Positive uptake in the lateral neck was recorded in 52 (11.4%) and in distant sites in 41 (9%) patients. Tracheal invasion, esophageal invasion, nerve invasion, and N1b classification were associated with a positive scan (P < .05). A positive radioactive iodine scan was not related to poor prognosis.

Conclusions: Posttreatment scans are positive in only 20% of patients. Locally invasive tumor and positive nodes are associated with positive scans.

Keywords: cancer; papillary carcinoma; radioiodine treatment; thyroid; whole-body scan.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma / diagnosis
  • Carcinoma / radiotherapy*
  • Carcinoma / surgery*
  • Female
  • Humans
  • Iodine Radioisotopes / pharmacokinetics*
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Predictive Value of Tests
  • Radionuclide Imaging
  • Radiopharmaceuticals / pharmacokinetics*
  • Retrospective Studies
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / radiotherapy*
  • Thyroid Neoplasms / surgery*
  • Thyroidectomy
  • Young Adult

Substances

  • Iodine Radioisotopes
  • Radiopharmaceuticals