Central nervous system granulocytic sarcoma: Report of 2 cases and review of the literature

Abstract

Granulocytic sarcomas are solid, extramedullary-located neoplasms composed of immature myeloid cells, associated with myeloproliferative syndromes. Central nervous system involvement is very rare and may develop either after complete remission, coexist with or precede the systemic disease, being the last one that guides the radiological diagnosis and marks the prognosis. In this work, we report 2 pathologically-verified cases of intracranial granulocytic sarcoma treated by surgical means. Their clinical, diagnostic, therapeutic and prognostic features are discussed in the light of the most relevant scientific literature published to date.

Keywords: Central nervous system; Chloroma; Cloroma; Granulocytic sarcoma; Myeloid sarcoma; Sarcoma granulocítico; Sarcoma mieloide; Sistema nervioso central.