Research of Cu-Doped Hydroxyapatite Microbeads Fabricated by Pneumatic Extrusion Printing

Wenchao Chi; Jiawei Zou; Fanrong Ai; Yanjun Lin; Wenchao Li; Chuanliang Cao; Kang Yang; Kui Zhou

doi:10.3390/ma12111769

Research of Cu-Doped Hydroxyapatite Microbeads Fabricated by Pneumatic Extrusion Printing

Materials (Basel). 2019 May 31;12(11):1769. doi: 10.3390/ma12111769.

Authors

Wenchao Chi¹, Jiawei Zou², Fanrong Ai^{3

4}, Yanjun Lin⁵, Wenchao Li⁶, Chuanliang Cao⁷, Kang Yang⁸, Kui Zhou^{9

10

11}

Affiliations

¹ School of Mechatronics Engineering, Nanchang University, Nanchang 330031, China. wcchi@email.ncu.edu.cn.
² School of Mechatronics Engineering, Nanchang University, Nanchang 330031, China. JiaweiZOU@email.ncu.edu.cn.
³ School of Mechatronics Engineering, Nanchang University, Nanchang 330031, China. aifanrong@ncu.edu.cn.
⁴ Key Laboratory of Lightweight and high strength structural materials of Jiangxi Province, Nanchang University, Nanchang 330031, China. aifanrong@ncu.edu.cn.
⁵ School of Mechatronics Engineering, Nanchang University, Nanchang 330031, China. yjlin@email.ncu.edu.cn.
⁶ School of Mechatronics Engineering, Nanchang University, Nanchang 330031, China. Chadli@ncu.edu.cn.
⁷ School of Mechatronics Engineering, Nanchang University, Nanchang 330031, China. cl_cao@ncu.edu.cn.
⁸ College of Pharmacy, Nanchang University, Nanchang 330031, China. yangkang@email.ncu.edu.cn.
⁹ School of Mechatronics Engineering, Nanchang University, Nanchang 330031, China. zhoukui@ncu.edu.cn.
¹⁰ Key Laboratory of Lightweight and high strength structural materials of Jiangxi Province, Nanchang University, Nanchang 330031, China. zhoukui@ncu.edu.cn.
¹¹ Engineering Science and Mechanics Department, Penn State University, University Park, PA 16802, USA. zhoukui@ncu.edu.cn.

Abstract

Copper is an indispensable micronutrient in human health, which has important effects on the promotion of angiogenesis and thus contributes to bone formation and antimicrobial activity. We used ion exchange and pneumatic printing methods to prepare hydroxyapatite (HA) microspheres with different copper content. The microspheres were characterized by scanning electron microscope (SEM), X-ray diffractometry (XRD) and X-Ray photoelectron spectroscopy (XPS). Considering the resistance of hydroxyapatite to biodegradation in vivo, the degradation rate of microspheres in modified simulated body fluids was studied. In addition, cell proliferation and antibacterial experiments were carried out to study the biological properties of microspheres. HA-1.5MCu microbeads treated by 1.5 mol/L CuSO₄ curing solution have good performance on degradation, antibacterial properties and cell survival rate on day 7. The results showed that HA-1.5MCu microbeads may be used as a good repair material for bone defects.

Keywords: biological performance; copper; hydroxyapatite; microbeads.

Abstract

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