Standpoint on the priority of TNTs and CNTs as targeted drug delivery systems

Yasmin Ranjous; Géza Regdon Jr; Klára Pintye-Hódi; Tamás Sovány

doi:10.1016/j.drudis.2019.05.019

Standpoint on the priority of TNTs and CNTs as targeted drug delivery systems

Drug Discov Today. 2019 Sep;24(9):1704-1709. doi: 10.1016/j.drudis.2019.05.019. Epub 2019 May 31.

Authors

Yasmin Ranjous¹, Géza Regdon Jr¹, Klára Pintye-Hódi¹, Tamás Sovány²

Affiliations

¹ University of Szeged, Institute of Pharmaceutical Technology and Regulatory Affairs, H-6720, Eötvös u. 6, Szeged, Hungary.
² University of Szeged, Institute of Pharmaceutical Technology and Regulatory Affairs, H-6720, Eötvös u. 6, Szeged, Hungary. Electronic address: t.sovany@pharm.u-szeged.hu.

PMID: 31158513
DOI: 10.1016/j.drudis.2019.05.019

Abstract

Conventional drug delivery systems have limitations according to their toxicity and poor solubility, bioavailability, stability, and pharmacokinetics (PK). Here, we highlight the importance of functionalized titanate nanotubes (TNTs) as targeted drug delivery systems. We discuss the differences in the physicochemical properties of TNTs and carbon nanotubes (CNTs) and focus on the use of functionalization to improve their characteristics. TNTs are promising materials for drug delivery systems because of their superb properties compared with CNTs, such as their processability, wettability, and biocompatibility. Functionalization improves nanoparticles (NPs) via their surface modification and enables them to achieve the targeted therapy.

Publication types

Review

MeSH terms

Biocompatible Materials
Drug Delivery Systems / methods*
Humans
Nanoparticles
Nanotubes / chemistry*
Nanotubes, Carbon / chemistry*

Substances

Biocompatible Materials
Nanotubes, Carbon