Osteoprotegerin and osteopontin levels, but not gene polymorphisms, predict mortality in cardiovascular diseases

Biomark Med. 2019 Jun;13(9):751-760. doi: 10.2217/bmm-2018-0458. Epub 2019 Jun 3.

Abstract

Aim: This study aims to investigate whether osteoprotegerin (OPG) or osteopontin (OPN) single nucleotide polymorphisms (SNPs) will predict survival. Materials & methods: This study enrolled 617 participants undergoing health examination, 536 coronary artery disease (CAD) patients and 86 peripheral artery disease (PAD) patients. Genotypes of OPG SNP rs2073618 and OPN SNP rs11730582 were determined. OPG and OPN levels were measured. Results: In both CAD and PAD populations, high OPG and OPN levels were strong predictors of all-cause death. The OPG rs2073618 CC genotype and the OPN rs11730582 TT genotype did not predict mortality. Conclusion: High OPG and high OPN levels, but not OPG rs2073618 CC genotype or OPN rs11730582 TT genotype, were strong predictors of mortality in both CAD and PAD patients.

Keywords: SNP; coronary artery disease; osteopontin; osteoprotegerin; peripheral artery disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Case-Control Studies
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / mortality
  • Female
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Osteopontin / blood*
  • Osteopontin / genetics*
  • Osteoprotegerin / blood*
  • Osteoprotegerin / genetics*
  • Peripheral Arterial Disease / blood*
  • Peripheral Arterial Disease / genetics*
  • Peripheral Arterial Disease / mortality
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Taiwan / epidemiology

Substances

  • Biomarkers
  • Genetic Markers
  • Osteoprotegerin
  • SPP1 protein, human
  • TNFRSF11B protein, human
  • Osteopontin