New compounds from the seeds of Psoralea corylifolia with their protein tyrosine phosphatase 1B inhibitory activity

Lu Ren; Le-Zhi Li; Jin Huang; Ling-Zhi Huang; Jiu-Hong Li; Ya-Min Li; Si-Yuan Tang

doi:10.1080/10286020.2019.1621852

New compounds from the seeds of Psoralea corylifolia with their protein tyrosine phosphatase 1B inhibitory activity

J Asian Nat Prod Res. 2020 Aug;22(8):732-737. doi: 10.1080/10286020.2019.1621852. Epub 2019 Jun 1.

Authors

Lu Ren¹, Le-Zhi Li¹, Jin Huang¹, Ling-Zhi Huang¹, Jiu-Hong Li¹, Ya-Min Li¹, Si-Yuan Tang²

Affiliations

¹ Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha 410008, China.
² Xiangya Nursing School of Central South University, Changsha 410008, China.

PMID: 31154855
DOI: 10.1080/10286020.2019.1621852

Abstract

Two new flavonoids, 5,4'-dihydroxy-6,7-furanbavachalcone (1), 1″-methoxy-6,7-furanflavanone (2), together with five known compounds (3-7), were isolated from the seeds of Psoralea corylifolia. Their structures were elucidated by IR, UV, NMR, HRESMS experiments, and comparison of their NMR data with previously reported data. All compounds were evaluated for in vitro inhibitory activity against PTP1B. Additionally, the isolated compounds (1-6) displayed moderate inhibitory effects against PTP1B with IC₅₀ values ranging from 10.3 ± 0.9 to 25.1 ± 1.6 μM.

Keywords: Leguminosae; PTP1B; Psoralea corylifolia; diabetes; flavonoid.

MeSH terms

Flavonoids
Molecular Structure
Protein Tyrosine Phosphatase, Non-Receptor Type 1*
Psoralea*
Seeds

Substances

Flavonoids
Protein Tyrosine Phosphatase, Non-Receptor Type 1