Neurocognitive and linguistic correlates of positive and negative formal thought disorder: A meta-analysis

Emre Bora; Berna Yalincetin; Berna Binnur Akdede; Köksal Alptekin

doi:10.1016/j.schres.2019.05.025

Neurocognitive and linguistic correlates of positive and negative formal thought disorder: A meta-analysis

Schizophr Res. 2019 Jul:209:2-11. doi: 10.1016/j.schres.2019.05.025. Epub 2019 May 29.

Authors

Emre Bora¹, Berna Yalincetin², Berna Binnur Akdede³, Köksal Alptekin³

Affiliations

¹ Department of Psychiatry, Dokuz Eylul University Medical School, Izmir 35340, Turkey; Department of Neuroscience, Dokuz Eylul University, Izmir 35340, Turkey; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia. Electronic address: emre.bora@deu.edu.tr.
² Department of Neuroscience, Dokuz Eylul University, Izmir 35340, Turkey.
³ Department of Psychiatry, Dokuz Eylul University Medical School, Izmir 35340, Turkey; Department of Neuroscience, Dokuz Eylul University, Izmir 35340, Turkey.

PMID: 31153670
DOI: 10.1016/j.schres.2019.05.025

Abstract

Executive dysfunction and language impairment are the most prominent neuropsychological models of formal thought disorder (FTD) in schizophrenia. However, available studies have provided contradictory findings regarding the accuracy of these models. Furthermore, specific neurocognitive underpinnings of positive FTD (PosFTD) and negative FTD (NegFTD) are not clear. Following the systematic review of schizophrenia studies, a random-effects meta-analysis of the relationship between FTD and neurocognition/language in schizophrenia was conducted in 52 reports including 2805 patients. Neurocognition was significantly associated with both PosFTD (r = -0.21, CI = -0.14 to -0.27) and NegFTD (r = -0.24, CI = -0.18 to -0.30). Both PosFTD (r = ranged from -0.18 to -0.27) and NegFTD (r = ranged from -0.19 to -0.23) were significantly correlated with verbal memory, visual memory, attention, and processing speed. In meta-analyses of executive functions, PosFTD was significantly associated with working memory (r = -0.21), planning (r = -0.19), and inhibition (r = -0.21) and NegFTD was significantly associated with planning (r = -0.27), fluency (r = -0.27), and working memory (r = -0.24). In meta-analyses of linguistic variables, PosFTD was associated with deficits in syntactic comprehension (r = -0.27) and semantic processing (r = -0.18). In contrast, NegFTD was associated only with semantic comprehension (r = -0.21). Both PosFTD and NegFTD were significantly associated with executive dysfunction, neurocognitive deficits and semantic dysfunction but syntactic deficits were more specific to PosFTD. There were also some distinct patterns of relationships between the pattern of executive dysfunction and types of FTD. Fluency deficit was associated more strongly with NegFTD and poor inhibition was more specifically related to PosFTD. Current findings suggest that neurocognitive and linguistic correlates of PosFTD and NegFTD might be partly different.

Keywords: Cognition; Formal thought disorder; Language; Schizophrenia.

Publication types

Meta-Analysis
Review

MeSH terms

Executive Function / physiology*
Humans
Language Disorders / physiopathology*
Mental Status and Dementia Tests
Schizophrenia / physiopathology*
Schizophrenic Language*
Schizophrenic Psychology*
Semantics
Stroop Test
Trail Making Test