The role of lipoxin in regulating tumor immune microenvironments

Ting Zhang; Hua Hao; Xiao-Yan Zhou

doi:10.1016/j.prostaglandins.2019.106341

The role of lipoxin in regulating tumor immune microenvironments

Prostaglandins Other Lipid Mediat. 2019 Oct:144:106341. doi: 10.1016/j.prostaglandins.2019.106341. Epub 2019 May 29.

Authors

Ting Zhang¹, Hua Hao², Xiao-Yan Zhou³

Affiliations

¹ Department of Pathophysiology, Medical College of Nanchang University, Nanchang 330006, China.
² Department of Pathology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
³ Department of Pathophysiology, Medical College of Nanchang University, Nanchang 330006, China; Jiangxi Province Key Laboratory of Tumor Etiology and Molecular Pathology, Nanchang 330006, China. Electronic address: zhouxiaoyan@ncu.edu.cn.

PMID: 31152809
DOI: 10.1016/j.prostaglandins.2019.106341

Abstract

The tumor immune microenvironment is the living environment for cancer cells which is essential for supporting cancer cells. Vascular endothelial cells and fibroblasts play a vital role in tumor metastasis and angiogenesis, while macrophages, neutrophils, lymphocytes, and other immune cells play an important role in cancer progression. Lipoxin (LX) is a class of eicosanoids that can regulate components of the innate and adaptive immune system, including the above cells. This review summarizes the roles of LX in the regulation of tumor immune microenvironments in order to throw light on the application of LX in the clinical treatment of tumor immune microenvironments.

Keywords: Immune cell; Lipoxin; Macrophage; Neutrophil; Tumor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Lipoxins / metabolism*
Neoplasms / immunology*
Neoplasms / metabolism*
Neoplasms / pathology
Tumor Microenvironment / immunology*

Substances

Lipoxins