Snatch-and-Grab Inhibitors to Fight the Flu

Adolfo García-Sastre

doi:10.1016/j.cell.2019.05.033

Snatch-and-Grab Inhibitors to Fight the Flu

Cell. 2019 May 30;177(6):1367. doi: 10.1016/j.cell.2019.05.033.

Author

Adolfo García-Sastre¹

Affiliation

¹ Department of Microbiology; Global Health and Emerging Pathogens Institute; and Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10128, USA. Electronic address: adolfo.garcia-sastre@mssm.edu.

PMID: 31150614
DOI: 10.1016/j.cell.2019.05.033

Abstract

Transcription of viral mRNA in cells infected with influenza viruses involves capturing and cleaving the first 10-20 nucleotides of 5' capped host mRNAs to be used as primers in viral RNA synthesis. A newly developed inhibitor of the viral endonuclease responsible for this cap-snatching shows therapeutic efficacy for the treatment of influenza. To view this Bench to Bedside, open or download the PDF.

MeSH terms

Dibenzothiepins
Endonucleases / genetics
Humans
Influenza, Human / drug therapy*
Morpholines
Orthomyxoviridae / drug effects
Orthomyxoviridae / pathogenicity
Oxazines / pharmacology*
Oxazines / therapeutic use*
Pyridines / pharmacology*
Pyridines / therapeutic use*
Pyridones
RNA Caps / genetics
RNA, Messenger / genetics
RNA, Viral / genetics
Thiepins / pharmacology*
Thiepins / therapeutic use*
Triazines / pharmacology*
Triazines / therapeutic use*
Viral Proteins / genetics

Substances

Dibenzothiepins
Morpholines
Oxazines
Pyridines
Pyridones
RNA Caps
RNA, Messenger
RNA, Viral
Thiepins
Triazines
Viral Proteins
baloxavir
Endonucleases