Exploring the effects of COLOSTRONONI on the mammalian gut microbiota composition

Sabrina Duranti; Leonardo Mancabelli; Walter Mancino; Rosaria Anzalone; Giulia Longhi; Rosario Statello; Luca Carnevali; Andrea Sgoifo; Sergio Bernasconi; Francesca Turroni; Marco Ventura

doi:10.1371/journal.pone.0217609

Exploring the effects of COLOSTRONONI on the mammalian gut microbiota composition

PLoS One. 2019 May 31;14(5):e0217609. doi: 10.1371/journal.pone.0217609. eCollection 2019.

Authors

Affiliations

¹ Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
² GenProbio srl Parma, Parma, Italy.
³ Stress Physiology Laboratory, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
⁴ Microbiome Research Hub, University of Parma, Parma, Italy.

Abstract

COLOSTRONONI is a dietary supplement consisting of bovine colostrum and Morinda citrifolia fruit (Noni). In this study, we tested the capability of COLOSTRONONI to influence gut microbiota composition using an in vivo evaluation in rats. Furthermore, we analyzed the effect of COLOSTRONONI on the systemic inflammatory responses as well as on the gut permeability of the animals. Altogether, our analyses supported the concept of COLOSTRONONI as a natural food supplement that doesn't affect (neither negatively nor positively) gut microbiota homeostasis in healthy conditions. Moreover, COLOSTRONONI highlighted a lower effect in the expression of genes coding for IL-10, Il-12 and TNF-α response allowing us to hypothesize an immunomodulatory activity of this dietary supplement.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cattle
Cytokines / genetics*
Dietary Supplements
Fruit / chemistry
Gastrointestinal Microbiome / drug effects*
Gastrointestinal Microbiome / genetics
Interleukin-10 / genetics
Interleukin-12 / genetics
Morinda / chemistry
Phytotherapy
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Rats
Tumor Necrosis Factor-alpha / genetics

Substances

Cytokines
Plant Extracts
Tumor Necrosis Factor-alpha
Interleukin-10
Interleukin-12

Grants and funding

GenProbio srl supports the Laboratory of Probiogenomics. The funder provided support in the form of salaries for R.A. and G.L. and research materials, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.