Spiropyrans have played a pivotal role in the emergence of the field of chromism following their discovery in the early 20th century, with almost ubiquitous use in materials applications especially since their photochromism was discovered in 1952. Their versatility continues to lend them to application in increasingly diverse fields not least due to recent discoveries of properties that have expanded their utility extensively. This review provides an overview of their rich history and highlights the contemporary relevance of the spiropyrans.