Polycyclic polyprenylated acylphloroglucinols from Hypericum choisianum

Nat Prod Res. 2021 Jan;35(2):195-202. doi: 10.1080/14786419.2019.1619723. Epub 2019 May 31.

Abstract

Twenty-one polycyclic polyprenylated acylphloroglucinols, including three new compounds named as hyperichoisins A (3), B (14) and C (21), were isolated from the aerial parts of Hypericum choisianum. The structures of those new compounds were elucidated by analysis of mass, NMR data, and chiroptical properties. A bioassay showed that otogirinin B had significant inhibitory effect on cell proliferation of A549.

Keywords: Hyperichoisins A – C; Hypericum choisianum; NMR analysis; PPAPs.

MeSH terms

  • A549 Cells
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Proliferation / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Hypericum / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phloroglucinol / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Phloroglucinol