Conjugated-Polymer-Based Nanoparticles with Efficient NIR-II Fluorescent, Photoacoustic and Photothermal Performance

Chembiochem. 2019 Nov 4;20(21):2793-2799. doi: 10.1002/cbic.201900309. Epub 2019 Oct 1.

Abstract

Fluorescence imaging (FI) and photoacoustic imaging (PA) play important roles in the real-time assessment of cell-based therapies. However, the limitations of conventional organic fluorescence contrast agents and the narrow range of the emission wavelength in the first near-infrared (NIR-I) window (750-900 nm) hamper applications of fluorescence imaging in living subjects. Herein, we report the design and synthesis of a short-wave infrared FI contrast agent and PA contrast agent based on a conjugated polymer-poly{2,5-bis[(5-thiophen-2-yl)methylene]-3,6-bis(2-octyldodecyl)-2,5-dihydropyrazine}-and its use to construct multifunctional nanoparticles to simplify photothermal therapy.

Keywords: conjugated polymers; imaging agents; nanoparticles; photothermal conversion; second near-infrared.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Fluorescence
  • Humans
  • Hyperthermia, Induced
  • Mice, Nude
  • Microscopy, Electron, Transmission
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Optical Imaging / methods*
  • Phosphatidylethanolamines / chemistry
  • Photoacoustic Techniques / methods*
  • Phototherapy / methods*
  • Polyethylene Glycols / chemistry
  • Polymers / administration & dosage
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Spectrophotometry / methods

Substances

  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)
  • Phosphatidylethanolamines
  • Polymers
  • Polyethylene Glycols