Evaluation of the practice of dose-rounding in paediatrics

Int J Pharm Pract. 2020 Feb;28(1):107-110. doi: 10.1111/ijpp.12549. Epub 2019 May 29.

Abstract

Objectives: To investigate the rounding of prescribed drug doses for paediatric administration.

Methods: A cross-sectional medication chart review was conducted at a UK paediatric hospital. Proposed administration dose volumes were calculated for prescribed doses using available manufactured liquids measured with oral and intravenous syringes. Resulting percentage deviations in doses administered were calculated.

Results: Of 2031 doses observed, 524 (25.8%) required rounding. The majority of which were for children aged 1-12 months. Twenty-seven rounded doses deviated from the prescribed dose by more than 10%.

Conclusion: This study highlights the impact of dose-rounding in paediatrics and the need for standardisation.

Keywords: children; dose-rounding; paediatric dosing; paediatric practice.

MeSH terms

  • Child, Preschool
  • Cross-Sectional Studies
  • Dose-Response Relationship, Drug
  • Hospitals, Pediatric
  • Humans
  • Infant
  • Medication Errors / statistics & numerical data*
  • Pediatrics / standards*
  • Pharmaceutical Preparations / administration & dosage*
  • United Kingdom

Substances

  • Pharmaceutical Preparations