Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation

Chem Biol Interact. 2019 Aug 1:308:385-391. doi: 10.1016/j.cbi.2019.05.034. Epub 2019 May 26.
No abstract available

MeSH terms

  • Acetylcholinesterase / metabolism*
  • Animals
  • Cholinesterase Reactivators / pharmacology*
  • Cholinesterase Reactivators / toxicity
  • Data Analysis
  • Diaphragm / enzymology*
  • Dose-Response Relationship, Drug
  • GPI-Linked Proteins / metabolism
  • Male
  • Maximum Tolerated Dose
  • Oximes / pharmacology*
  • Oximes / toxicity
  • Pyridinium Compounds / pharmacology*
  • Pyridinium Compounds / toxicity
  • Rats, Wistar

Substances

  • 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene
  • 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide
  • Cholinesterase Reactivators
  • GPI-Linked Proteins
  • Oximes
  • Pyridinium Compounds
  • Acetylcholinesterase
  • Ache protein, rat