Linear-Dendritic Alternating Copolymers

Haotian Sun; Farihah M Haque; Yi Zhang; Alex Commisso; Mohamed Alaa Mohamed; Marina Tsianou; Honggang Cui; Scott M Grayson; Chong Cheng

doi:10.1002/anie.201903402

Linear-Dendritic Alternating Copolymers

Angew Chem Int Ed Engl. 2019 Jul 29;58(31):10572-10576. doi: 10.1002/anie.201903402. Epub 2019 Jun 27.

Authors

Haotian Sun¹, Farihah M Haque², Yi Zhang¹, Alex Commisso¹, Mohamed Alaa Mohamed^{1

3}, Marina Tsianou¹, Honggang Cui⁴, Scott M Grayson², Chong Cheng¹

Affiliations

¹ Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY, 14260, USA.
² Department of Chemistry, Tulane University, New Orleans, LA, 70118, USA.
³ Department of Chemistry, Mansoura University, Mansoura, 35516, Egypt.
⁴ Department of Chemical & Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.

PMID: 31141618
DOI: 10.1002/anie.201903402

Abstract

Herein, the design, synthesis, and characterization of an unprecedented copolymer consisting of alternating linear and dendritic segments is described. First, a 4th-generation Hawker-type dendron with two azide groups was synthesized, followed by a step-growth azide-alkyne "click" reaction between the 4th-generation diazido dendron and poly(ethylene glycol) diacetylene to create the target polymers. Unequal reactivity of the functional groups was observed in the step-growth polymerization. The resulting copolymers, with alternating hydrophilic linear and hydrophobic dendritic segments, can spontaneously associate into a unique type of microphase-segregated nanorods in water.

Keywords: alternating copolymers; click chemistry; linear-dendritic copolymers; nanorods; self-assembly.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

Abstract

Publication types

Grants and funding