Early listeriosis after liver transplantation: Report of two cases

Transpl Infect Dis. 2019 Aug;21(4):e13122. doi: 10.1111/tid.13122. Epub 2019 Jun 30.

Abstract

Listeria monocytogenes is a rare cause of potentially lethal infection and sepsis in transplant recipients. Listeriosis is usually described after kidney or bone marrow transplant, and has been less frequently reported after liver transplantation. Here, the authors present two cases of severe Listeria infection occurring within 4 months after complicated liver transplantation in patients still recovering on the ward. The patients were successfully treated by intravenous ampicillin. These cases should remind transplant physicians that listeriosis may develop in liver transplant recipients, that food safety advice should be provided, and that intravenous ampicillin might be an effective treatment for systemic listeriosis in solid organ recipients. It is likely that trimethoprim-sulfamethoxazole prophylaxis might help prevent early listeriosis after solid organ transplantation.

Keywords: ascites; complications; infection; listeria monocytogenes; liver transplantation; meningitis; peritonitis; sepsis.

Publication types

  • Case Reports

MeSH terms

  • Ampicillin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Female
  • Humans
  • Listeria monocytogenes / drug effects
  • Listeriosis / diagnosis*
  • Listeriosis / drug therapy
  • Liver Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Postoperative Complications / microbiology*
  • Sepsis / drug therapy
  • Sepsis / microbiology
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Ampicillin
  • Trimethoprim, Sulfamethoxazole Drug Combination