World Workshop on Oral Medicine VII: Clinical evidence of differential expression of lncRNAs in oral squamous cell carcinoma: A scoping review

Monica Pentenero; Leah M Bowers; Ruwan Jayasinghe; Tami Yap; Sok Ching Cheong; Alexander Ross Kerr; Camile S Farah; Ilias Alevizos

doi:10.1111/odi.13076

World Workshop on Oral Medicine VII: Clinical evidence of differential expression of lncRNAs in oral squamous cell carcinoma: A scoping review

Oral Dis. 2019 Jun;25 Suppl 1(Suppl 1):88-101. doi: 10.1111/odi.13076.

Authors

Monica Pentenero¹, Leah M Bowers², Ruwan Jayasinghe³, Tami Yap⁴, Sok Ching Cheong⁵, Alexander Ross Kerr⁶, Camile S Farah⁷, Ilias Alevizos⁸

Affiliations

¹ Department of Oncology, Oral Medicine and Oral Oncology Unit, University of Turin, Turin, Italy.
² Department of Stomatology, Division of Oral Medicine, Medical University of South Carolina, Charleston, SC, USA.
³ Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.
⁴ Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia.
⁵ Head and Neck Cancer Research Team, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
⁶ New York University College of Dentistry, New York, NY, USA.
⁷ Australian Centre for Oral Oncology Research & Education, UWA Dental School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia.
⁸ Sjogren's Syndrome and Salivary Gland Dysfunction Unit, NIDCR/NIH, Bethesda, MD, USA.

Abstract

Background: Long non-coding RNAs (lncRNAs) have important roles in regulating gene expression pertaining to cell proliferation, survival, migration and genomic stability. Dysregulated expression of lncRNAs is implicated in cancer initiation, progression and metastasis.

Objectives: To explore, map and summarize the extent of evidence from clinical studies investigating the differential expression of lncRNAs in oral/tongue squamous cell carcinoma.

Methods: PubMed, Scopus and Web of Science were used as search engines. Clinical, full-length, English language studies were included. PRISMA-ScR protocol was used to evaluate and present results. The present scoping review summarizes relationships of the differential expression of lncRNAs with the presence of tumour and with clinicopathological features including survival.

Results: Almost half of the investigated transcripts have been explored in more than one study, yet not always with consistent results. The collected data were also compared to the limited studies investigating oral epithelial dysplasia. Data are not easily comparable, first because of different methods used to define what differential expression is, and second because only a limited number of studies performed multivariate analyses to identify clinicopathological features associated with the differentially expressed lncRNAs.

Conclusions: Standard methods and more appropriate data analyses are needed in order to achieve reliable results from future studies.

Keywords: GAS5; H19; HIFCAR; HOTAIR; HULC; LINC00152; LINC00673; MALAT1; MEG3; NEAT1; UCA1; epigenetics; lncRNA; oral squamous cell carcinoma.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / pathology
Congresses as Topic
Humans
Mouth Neoplasms / genetics*
Mouth Neoplasms / pathology
RNA, Long Noncoding / genetics*
Tongue Neoplasms / genetics*
Tongue Neoplasms / pathology

Substances

RNA, Long Noncoding

Abstract

Publication types

MeSH terms

Substances

Grants and funding