Two new physalin derivatives from Physalis alkekengi L. var. franchetii (Mast.) Makino

Jian-Lu Sun; Yong-Jun Jiang; Lin Cheng

doi:10.1080/14786419.2019.1619724

Two new physalin derivatives from Physalis alkekengi L. var. franchetii (Mast.) Makino

Nat Prod Res. 2021 Jan;35(2):203-206. doi: 10.1080/14786419.2019.1619724. Epub 2019 May 29.

Authors

Jian-Lu Sun^{1

2}, Yong-Jun Jiang³, Lin Cheng²

Affiliations

¹ Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin, PR China.
² Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, PR China.
³ Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan, PR China.

PMID: 31140313
DOI: 10.1080/14786419.2019.1619724

Abstract

Two new physalin derivatives named 7β-ethoxyl-isophysalin C (1) and 3β-ethoxyl-2,3-dihydro-4,7-didehydrophysalin B (2) were isolated from Physalis alkekengi L. var. franchetii (Mast.) Makino. Their structures were determined by extensive NMR-spectroscopic analysis and HRESIMS data. Compounds 1 and 2 were tested for their cytotoxicity against PC-3 cancer cell lines. Compound 1 showed apparent moderate with IC₅₀ values of 8.26 μM, whereas compound 2 exhibited no cytotoxicity against PC-3 cancer cell lines.

Keywords: 3β-ethoxyl-2,3-dihydro-4,7-didehydrophysalin B; 7β-ethoxyl-isophysalin C; Physalis alkekengi L. var. franchetii (Mast.) Makino.

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Male
Molecular Structure
PC-3 Cells
Physalis / chemistry*
Withanolides / chemistry*
Withanolides / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Withanolides