HLA Class-II Expression in Human Tumors

Federico Garrido

doi:10.1007/978-3-030-17864-2_4

HLA Class-II Expression in Human Tumors

Adv Exp Med Biol. 2019:1151:91-95. doi: 10.1007/978-3-030-17864-2_4.

Author

Federico Garrido¹

Affiliation

¹ Departamento de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Facultad de Medicina, Universidad de Granada, Granada, Spain.

PMID: 31140108
DOI: 10.1007/978-3-030-17864-2_4

Abstract

HLA class II molecules play a pivotal role in antigen presentation to T lymphocytes. This chapter analyzed the expression of these molecules in different human tumors and their role in cancer progression. The possible connection between tumor HLA class II expression and the pathogenesis of autoimmune diseases is discussed.

Keywords: Antigen presenting cells; Cytokynes; HLA-II & autoimmunity; HLA-II in tissues; HLA-II in tumors; Immunohistochemistry; Interferon; Tumor infiltrating lymphocytes; Tumor prognosis; Tumor rejection.

Publication types

Review

MeSH terms

Histocompatibility Antigens Class II / genetics*
Humans
Neoplasms / immunology*
T-Lymphocytes

Substances

Histocompatibility Antigens Class II