Ru(TAP)32+ uses multivalent binding to accelerate and constrain photo-adduct formation on DNA

Chem Commun (Camb). 2019 Jul 23;55(60):8764-8767. doi: 10.1039/c9cc02838b.

Abstract

Ru(ii)-complexes with polyazaaromatic ligands can undergo direct electron transfer with guanine nucleobases on blue light excitation that results in DNA lesions with phototherapeutic potential. Here we use single molecule approaches to demonstrate DNA binding mode heterogeneity and evaluate how multivalent binding governs the photochemistry of [Ru(TAP)3]2+ (TAP = 1,4,5,8-tetraazaphenanthrene).

MeSH terms

  • DNA / chemistry*
  • DNA Adducts / chemical synthesis
  • Guanine / chemistry
  • Intercalating Agents / chemistry*
  • Intercalating Agents / radiation effects
  • Ligands
  • Light
  • Nucleic Acid Conformation
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / radiation effects
  • Phenanthrenes / chemistry*
  • Phenanthrenes / radiation effects
  • Phenanthrolines / chemistry
  • Phenanthrolines / radiation effects
  • Ruthenium / chemistry

Substances

  • DNA Adducts
  • Intercalating Agents
  • Ligands
  • Organometallic Compounds
  • Phenanthrenes
  • Phenanthrolines
  • tris-(1,10-phenanthroline)ruthenium
  • Guanine
  • Ruthenium
  • ruthenium-tris-1,4,5,8-tetraazaphenanthrene
  • DNA